Vitamin D and Type 2 Diabetes Risk in UK Adults

Liverpool Hope University300 enrolled

Overview

This study is exploring the association between vitamin D and Type 2 diabetes risk in normal weight and overweight UK adults.

The aim of this study is to assess the link between vitamin D status and glucose homeostasis in a population of normal weight and overweight individuals (BMI\> 18.5 Kg/m2).

Study Type

OBSERVATIONAL

Enrollment

300

Conditions

Overweight Obesity

Interventions

Normal weight and overweight adultsOTHER

Association between vitamin D levels and insulin resistance

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Normal weight and overweight and obese adults (BMI\>= 18.5 Kg/m2) with no restriction to ethnicity, occupation or socioeconomic status. * Males and females * 18-50 years Exclusion Criteria: * Patients diagnosed with diabetes type 2, myocardial infarction or coronary heart disease. * HbA1c \> 6.4% * Pregnancy * Diagnosis of liver disease (including liver enzymes \> 3 times above normal values) * Diagnosis of renal disease (creatinine of \> 150 mmol/l) * Post-menopausal women

Locations (1)

School of Health sciences

Liverpool, United Kingdom

Outcomes

Primary Outcomes

HOMA-IR (Homeostasis modelling assessment-Insulin resistance)

A venous blood sample collected for the measurement of insulin and glucose levels.

Time frame: One venous sample collected after 8 hours of fasting

Secondary Outcomes

Fasting bood glucose levels

A venous blood sample collected for the measurement of glucose levels

Time frame: One venous sample collected after 8 hours of fasting

HbA1C

Fingerprick sample

Time frame: Sample collected at one single time point with no follow-up

Body fat percentage

Body fat percentage measured through DEXA

Time frame: Measurement conducted in the morning after 8 hours of fasting

Central and brachial Systolic and Diastolic Blood pressure

Blood pressure measured using a digital sphygmomanometer

Time frame: Measurement taken 3 times after a-10 minute rest

Augmentation index

Arterial stiffness assessment test

Time frame: Measurement taken 3 times after a-10 minute rest

Data from ClinicalTrials.gov

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