Gut Microbiota Metagenomics for Chronic Liver Disease

Chuncheon Sacred Heart Hospital3,240 enrolled

Overview

Gut microbiota modulation has effect on chronic liver disease

Chronic liver disease has been known as a disease of the liver which lasts over a period of 6-month. It consists of inflammation, hepatitis, cirrhosis, hepatocellular carcinoma. Gut microbiota plays an important roles in the chronic liver disease. It can suppress the progression of the liver disease by moulation gut microbiota. The investigators are still evaluating the effect of gut microbiota on the liver disease.

Study Type

OBSERVATIONAL

Enrollment

3,240

Conditions

Liver Disease Chronic

Interventions

DNA extractionOTHER

Extraction fecal DNA and compare disease group to normal group

Eligibility

Sex: ALLMin age: 31 YearsMax age: 82 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age 19+ * Normal : AST or ALT level \< 50IU/L, BMI \< 25 * Liver disease : AST or ATL level ≥ 50IU/L, BMI ≥ 25 * Patients hospitalized with chronic liver disease (viral hepatitis, alcoholic liver disease, non-alcoholic liver disease, cirrhosis, liver cancer) Exclusion Criteria: * Normal : AST or ATL level ≥ 50IU/L, BMI ≥ 25 * Liver disease : AST or ALT level \< 50IU/L, BMI \< 25 * If the patient refuses

Locations (1)

Department of Internal Medicine, Hallym University Chuncheon Sacred Heart Hospital

Chuncheon, South Korea

Outcomes

Primary Outcomes

Fecal DNA

Compare the species and proportions of the gut microbiome

Time frame: 10 years

Liver enzyme

Compare the liver enzyme level

Time frame: 10 years

BMI

Compare the body mass index

Time frame: 10 years

Data from ClinicalTrials.gov

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