Patients with cancers that are sensitive to radiotherapy treatment and/or patients who have experienced severe acute/ late side effects to radiotherapy will be recruited to the study. Blood and/or matched tumour-normal tissue pairs will be collected. Blood and/or tissue samples will be processed and studied for genetic and biochemical markers that have potential to be used for predicting sensitivity to radiation.
Study Type
OBSERVATIONAL
Enrollment
5,000
National Cancer Center Singapore
Singapore, Singapore
To identify genes or molecular pathways that are associated with radiation sensitivity in blood and tissue samples
Whole exome sequencing, single nucleotide polymorphism (SNP) assays
Time frame: Blood is taken at informed consent; tissue is from archived sample
Change in immune profile of blood and tissue after radiation
Mass cytometry using CyTOF technology will be used to detect the immune cell population
Time frame: Blood is taken at informed consent; tissue is from archived sample
To identify proteins that are associated with radiation sensitivity in tissue samples
Immunohistochemistry will be used to detect protein expression
Time frame: Tissue is from archived sample
To identify RNA expression pathways that are associated with radiation sensitivity in blood and tissue samples
RNA sequencing
Time frame: Blood is taken at informed consent; tissue is from archived sample
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