Gastric carcinoma is the second most common cause of cancer-related deaths and its main treatment modality if potentially curable is surgery but the optimal surgical resection is controversial. The aim of the current study was to assess the outcomes of curative D2 compared to D1 gastrectomy of operable gastric carcinoma regarding postoperative morbidity and mortality, disease recurrence and survival rates.
80 consecutive patients with potentially operable gastric carcinoma were randomized via concealed envelopes into 2 groups (each included 40 patients), group I managed by radical gastrectomy with D1 lymphadenectomy while group II managed by radical gastrectomy with D2 lymphadenectomy . Both groups were compared regarding postoperative mortality, morbidities, tumor recurrence and 2 years survival rates.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
80
Radical gastrectomy with D1 lymphadenectomy
Radical gastrectomy with D2 lymphadenectomy
Postoperative morbidity rate
Frequency of early postoperative complications
Time frame: 30 days after surgery
Operative mortality rate
Frequency of early postoperative mortality
Time frame: Within 30 days after surgery
2 years Recurrence rate
Frequency of tumor recurrence within 2 years after curative surgery
Time frame: 2 years after surgery
2 years Cancer specific mortality rate
Frequency of patients died because of gastric cancer within 2 years after curative surgery
Time frame: 2 years after surgery
2 years Disease free survival rate
Percentage of patients survived for 2 years without tumor recurrence
Time frame: 2 years after surgery
2 years Overall survival rate
Percentage of patients survived for 2 years with/without tumor recurrence
Time frame: 2 years after surgery
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