This is an open-label, multicenter, randomized, phase3 trial to evaluate the efficacy of Camrelizumab in patients with relapsed or refractory classic Hodgkin's lymphoma. Participants will be randomized to receive either Camrelizumab monotherapy or chemotherapy of investigators' choice. The primary hypotheses of this study are that treatment with Camrelizumab prolongs Progression-free Survival (PFS) in participants with relapsed or refractory Classical Hodgkin Lymphoma compared to treatment with Chemotherapy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
56
A humanized monoclonal immunoglobulin
Participants will receive one of the following chemotherapies for up to 6 cycles: Gemox: Gemcitabine and Oxaliplatin; IGEV: Ifosfamide, Gemcitabine, Vinorelbine, and Prednisolone; DHAP: Dexamethasone, high-dose Cytarabine (Ara-C) and Cisplatin.
Jiangsu Cancer Hospital
Nanjing, Jiangsu, China
RECRUITINGProgression Free Survival (PFS)
Time from randomisation to radiologically confirmed progressive disease
Time frame: anticipated 16 months
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