The purpose of this study is to examine the effect of Cequa treatment on the accuracy of pre-operative biometry and on corneal higher-order aberrations (HOAs) in cataract patients who have signs of dry eye disease.
Hypothesis: In patients with dry eye, defined as corneal staining and a reduced tear breakup time, the accuracy of pre-operative biometry and corneal surface HOAs will improve significantly after four weeks of Cequa treatment. Primary Outcome Measure: Spherical equivalent prediction error of pre-Cequa vs post-Cequa ocular biometry performed for cataract surgery. Secondary Outcome Measures: The impact of Cequa treatment on corneal higher order aberrations measured in the central 6 mm of the cornea. The difference in SPEED questionnaire scores before and 4 weeks after Cequa treatment. The difference in corneal staining and tear breakup time (TBUT) before and after treatment with Cequa.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
74
The effect of Cequa treatment on the accuracy of pre-operative biometry and on corneal higher-order aberrations (HOAs) in cataract patients who have signs of dry eye disease.
Harvard Eye Associates
Laguna Hills, California, United States
Ophthalmology Associates
St Louis, Missouri, United States
Ophthalmic Surgeons & Consultants of Ohio
Columbus, Ohio, United States
Spherical equivalent prediction error of pre-Cequa vs post-Cequa ocular biometry performed for cataract surgery.
Time frame: Four weeks
The impact of Cequa treatment on corneal higher order aberrations measured in the central 6 mm of the cornea.
Time frame: Four Weeks
The difference in SPEED questionnaire scores before and 4 weeks after Cequa treatment.
To compare the difference in Standard Patient of Eye Dryness Questionnaire (SPEED) scores before and after 4 weeks of therapy with Cequa BID among patients with significant dry eye (decreased TBUT or corneal staining) with planned cataract surgery. The SPEED questionnaire gives a score from 0-28 that is the result of 8 items that assess frequency and severity of symptoms. Speed Score Severity rating: 0-4 Mild, 5-7 Moderate, 8+ Severe.
Time frame: Four Weeks
The difference in corneal staining before and after treatment with Cequa.
The presence of central or inferior corneal fluorescein staining defined by the Oxford Scale.
Time frame: Four Weeks
The difference in tear breakup time (TBUT) before and after treatment with Cequa.
Reduced tear break up time (TBUT) ≤ 10 seconds.
Time frame: Four Weeks
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