Effectiveness of Ivermectin as add-on Therapy in COVID-19 Management

University of Baghdad16 enrolled

Overview

Comparing the effectiveness of Ivermectin( IVM) +Hydroxychloroquin + azithromycin (AZT) group to Hydroxychloroquin (HCQ) + azithromycin (AZT)

Comparing effectiveness of single dose 0.2mg/kg Ivermectin (IVM) plus hydroxychloroquine (HCQ) 400mg BID in first day then 200mg BID for 5 days plus azithromycin (AZT) 500mg in first day then 250mg for 5 days. The comparison group was a historical control population and data collected from the current study were compared to that historical control population

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

COVID 19

Interventions

Ivermectin (IVM)DRUG

Ivermectin 0.2 mg /kg (single dose at once =2 tablets of 6mg/weekly

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: -1. Patients with age above 18 years and any gender with definite Dx of covid19 and pneumonia in the ward according to the clinical, laboratory, and imaging criteria. 2\. Understands and agrees to comply with planned study procedures. Exclusion Criteria: 1. Patients with hypersensitivity or severe adverse effects to Ivermectin 2. Renal impairment 3. Hepatic impairment. 4. Pregnancy or a desire to become pregnant (drug considered pregnancy category c) 5. Breast feeding. 6. Patient with covid 19 positive and mild no pneumonia 7. Children under the age of five or those who weigh less than 15 kilograms

Locations (1)

General Directorate of Medical City

Baghdad, Baghdad Governorate, Iraq

Outcomes

Primary Outcomes

Number of Cured Patients

Primary outcome is assessed by calculating the number of patients who had symptoms free and two successive readings of negative PCR swab.

Time frame: 4 weeks

Secondary Outcomes

Time to Cure of COVID-19 Patients in the IVM +HCQ+AZT Group

Time to cure is evaluated by measuring time from admission of the patient to the hospital till discharge after being free of symptoms and negative PCR swab. Once nasopharyngeal and oropharyngeal swab viral PCR testing yielded negative results 2 times consecutively, no further testing was performed

Time frame: 4 week

Data from ClinicalTrials.gov

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