Prevention of SARS-CoV-2 in Hospital Workers s Exposed to the Virus

Inclusion Criteria: Hospital workers working at AP-HP hospitals over the age of 18 * Hospital workers who have signed consent * No signs of COVID-19 infection * Women who are likely to procreate should have a negative pregnancy test on inclusion day. In addition, they should use at least one effective contraceptive method before starting treatment, during treatment and up to 8 months after the last drug tested during the trial. Sexually active men should also have effective contraception during treatment and for at least 8 months after the last drug tested during the trial. * Affiliated or beneficiary of Social Security Exclusion Criteria: * History of SARS-CoV-2 infection confirmed by PCR or serology is available at inclusion * A history of clinical episode suspecting a PCR-confirmed or unconfirmed COVID-19 infection. * Pregnancy and breastfeeding * Allergy or contraindications to one of the 2 drugs in the study * Known retinopathy * Long congenital QT syndrome (or known in the family) * QTc or 450 ms in men, or 460 ms in women, if Fc 55/mn (except in case of intense sport practice), if ESV on baseline ECG, if QRS - or 120 ms, if AC/FA, if the PR or BAV lengthening * History of severe ischemic heart disease or unbalanced heart failure. * Clinically significant bradycardia known * Known kidney or liver failure * Known G6PD deficit * Subject who received antiviral treatment in the 14 days prior to inclusion * Subject who had treatment with azithromycin or hydroxychloroquine, in the 14 days prior to inclusion * Hypokaliemia (\<= 3.5 mmol/L), Increase in creatinine (\>=120 micromol/Ll, Increase in transaminases at baseline (\>=2N)