Treatment in Patients With Suspected or Confirmed COVID-19 With Early Moderate or Severe Disease

Inclusion Criteria: * Age greater than 18 years * Positive SARS-CoV-2 testing or consistent clinical syndrome (based on clinical picture e.g. characteristic infiltrates on chest x-ray, laboratory findings, and with agreement by two physicians) in patients under investigation (PUIs). * Onset of symptoms \< 7 days from date of enrollment * Oxygen saturation of \>94% on room air with defined risk factors (Table 1) consistent with moderate disease OR oxygen saturation of \< 94% on room air consistent with severe disease * Ability and willingness to comply with study procedures Exclusion Criteria: * QTc greater than 450 milliseconds on screening EKG * Pregnant or lactating women * Inability to take oral pills or inability to use a feeding tube * Inability to obtain informed consent either from the patient or from the next of kin if patient is incapacitated. For the purpose of this study obtaining a verbal consent from a family member on the phone with a witness will be considered acceptable since there is a 'no visitor' policy in force at hospitals. * Patients requiring ICU level care * use of azithromycin or hydroxychloroquine within 30 days prior to admission