Convalescent Plasma vs. Standard Plasma for COVID-19

There are 2 groups of research subjects: plasma donor and recipients Volunteer plasma donors can donate Convalescent Plasma if they: * have adequate antibody levels against COVID-19 per FDA Guidelines * have had no symptoms of COVID-19 for at least 14 days * meet routine plasma donation criteria Inclusion Criteria for Plasma Recipients: * Adults 18 years of age or older * Hospitalized with PCR+ COVID-19 infection * If female must not be pregnant and/or breastfeeding. Exclusion Criteria for Plasma Recipients: * Unable to randomize patient within 14 days of admission to Stony Brook Hospital (or any other hospital if a transfer to Stony Brook Hospital). * In the treating physician's opinion, the patient cannot tolerate a 450-550 mL infusion of plasma over up to 8 hours (4 hours max per unit), even if prophylaxed with intravenous diuretic * Contraindication to transfusion or history of prior reactions to blood transfusions