Necrotizing enterocolitis (NEC) is a gastrointestinal system disease characterized by inflammatory necrosis of the intestine mainly seen in premature infants, and continues to be an important cause of mortality and morbidity in neonatal intensive care units all over the world. Although it is more common in premature infants, it is also seen in term babies when the intestine is ischemic. Although the major problem in premature babies is the immaturity of the intestine, many factors contributing to immaturity play a role in the pathogenesis of NEC.
Necrotizing enterocolitis (NEC) is a gastrointestinal system disease characterized by inflammatory necrosis of the intestine mainly seen in premature infants, and continues to be an important cause of mortality and morbidity in neonatal intensive care units all over the world. Although it is more common in premature infants, it is also seen in term babies when the intestine is ischemic. Although the major problem in premature babies is the immaturity of the intestine, many factors contributing to immaturity play a role in the pathogenesis of NEC. With this study project, which is planned as a national multicenter prospective study, the incidence of necrotizing enterocolitis in newborn infants born in neonatal intensive care units in our country and the risk factors associated with the NEC, especially the detailed feeding history of the patient (when the first feeding is nourished, antibiotics and other treatments that are being used). Most epidemiological data such as the most common stage of the disease, treatment, prognosis, comparison with the data of other countries will provide important information for the neonatal health of our country. The aim of this study was to determine the factors affecting the emergence of NEC in neonatal intensive care units and to determine the frequency of NEC. Study Hypothesis: Delayed enteral feeding, intensive use of antibiotics and nutrients other than breast milk increase the incidence of necrotizing enterocolitis.
Study Type
OBSERVATIONAL
Enrollment
500
With this project, which is planned as a national multicenter prospective study, the incidence of necrotizing enterocolitis in newborn infants born in newborn intensive care units in our country and the risk factors associated with the disease, especially the detailed feeding history of the patient (when the first feeding is nourished, antibiotics and other treatments that are being used). Most epidemiological data such as the most common stage of the disease, treatment, prognosis, comparison with the data of other countries will provide important information for the neonatal health of our country.
Tolga Hasan Çelik, MD
Ankara, Turkey (Türkiye)
Tolga Hasan Çelik
Ankara, Turkey (Türkiye)
Incidence of Necrotizing Enterocolitis
Incidence: frequency of NEC during study period
Time frame: 1 year
Risk factors for mild and severe necrotizing enterocolitis
erytrocyte/FFP/trombocyte transfusions,PDA closing therapy, umbilical artery catheterisation,
Time frame: 1 year
Initiation of enteral feeding time, choice of breastfeeding or formula
nutrition: breastfeeding of formula, delayed enteral feeding
Time frame: 1 year
Meconium discharge time
meconium discharge time (hour)
Time frame: 1 year
probiotic usage
probiotic usage, type of probiotic preparation
Time frame: 1 year
severity of necrotizing enrerocolitis
Grade of NEC disease according to modified Bell Criteria
Time frame: 1 year
Prognosis
complications: intestinal perforation, requirement of surgery, short bowell syndrome), mortality rate.
Time frame: 1 year
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