The purpose of this study is to evaluate the efficacy of Acetyl-L-carnitine in patient with Mild Cognitive Impairment associated with chronic cerebrovascular disease.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
636
The participants will receive treatment of Acetyl-L-carnitine hydrochloride 500mg, orally, 3 times a day for 24weeks
The participants will receive treatment of placebo of Acetyl-L-carnitine hydrochloride 500mg, orally, 3 times a day for 24weeks
Catholic Kwandong University International St. Mary'S Hospital
Incheon, South Korea
RECRUITINGInterference score using K-CWST(Korean-Color Word Stroop Test)
interference score is defined as 'the time required to test stage 2(Color-Word)' minus ''the time required to test stage 1(Word)
Time frame: 24 week
Montreal Cognitive Assessment Korean(MOCA-K)
MOCA-K included cognitive domains; attention and concentration, executive functions, memory, language, visuoconstructional skills, conceptual thinking, calculations, and orientation. MOCA-K scored from 0 to 30. The higher the score, the better.
Time frame: 24 week
Korean Trail Making Test Elderly(K-TMT-e)
The K-TMT-e was composed of 2 parts: part A calls for the test-taker to connect randomly distributed numbers (1-25) on a test paper in ascending order (1-\>2-\>3...), whereas part B requires the test-taker to alternate numbers and letters (1-\>A-\>2-\>B...).
Time frame: 24 week
EQ-5D
EQ-5D included 5 dimensions; mobility, self-care, usual activities, pain/discomfort, and anxiety/depression.
Time frame: 24 week
Clinical Global Impression -Improvement (CGI-I)
CGI-I scored from 1 (very much improved) to 7 (very much worse).
Time frame: 24 week
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