Hyaluronidase in Intra-articular Steroid Injection Treating the Adhesive Capsulitis for Shoulder

Veterans Health Service Medical Center, Seoul, Korea30 enrolled

Overview

Adhesive capsulitis (AC) is painful and disabling condition that is associated with a gradual loss of shoulder motion. Intra-articular steroid injection is a common treatment in the initial painful stage of AC, and its use in combination with hyaluronidase may offer increased therapeutic efficacy owing to synergistic effects. We determined the therapeutic efficiency of the co-administration of hyaluronidase in early AC by evaluating symptomatic, anthropometric, and imaging changes.

We enrolled eligible patients with primary adhesive capsulitis in the initial stage.The subjects were randomly assigned into 3 groups to receive ultrasound-guided intra-articular injections with 20 mg (group A) and 40 mg triamcinolone acetonide (group B) and 20 mg acetonide combined with hyaluronidase (group C). The outcome measures included the visual analogue scale (VAS), the shoulder disability questionnaire (SDQ), abduction and external rotation range of motion, and intra-sheath fluid (ISF) before treatment and at 2, 4, 8, and 16 weeks after treatment.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Adhesive Capsulitis of Shoulder

Interventions

Triamcinolone Acetonide 40mg/mLDRUG

We aimed to examine the therapeutic efficacy of the combination of hyaluronidase and steroid injection for adhesive capsulitis and to determine whether such a combination therapy might enable the total amount of steroids to be reduced.

Hyaluronidase InjectionDRUG

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Normal findings on simple x-rays of the shoulder but limitations in passive range of motion on physical examination * Increased intra-sheath fluid (ISF) sufficient to encircle the long head of the biceps tendon within the upper portion of the bicipital groove of the humerus. Exclusion Criteria: * Ultrasonographic diagnosis of other concomitant fundamental abnormalities causing shoulder pain such as rotator cuff tear, bicipital tendon rupture, calcific tendinopathy, and subacromial-subdeltoid bursitis * A history of shoulder injury * A history of more than 1 year of conservative treatment for chronic shoulder pain * Corticosteroid or hyaluronidase injections within the prior 6 months * Hemiplegic shoulder * Self-reported history consistent with scapula fracture or disarticulation * Ipsilaterally cervical herniated intervertebral disc or brachial plexus injury * Diabetes mellitus refractory to insulin therapy or glycated hemoglobin greater than 6.5 * Refusal to participate in this study

Locations (1)

Veterans Health Service Medical Center

Seoul, South Korea

Outcomes

Primary Outcomes

Change of visual analogue scale (VAS)

Evaluation for the change of VAS that means average degree of shoulder pain for 24 hours before the evaluation (from 0 to 10 points)