The aim of the COVI-PRONE Trial is to determine if early awake prone positioning in COVID-19 patients with hypoxemic respiratory failure; irrespective of the mode of oxygen delivery; reduces the need for invasive mechanical ventilation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
400
The duration of proning will be a total of 8-10 hours with 1-2 hours break in supine position.
University of Texas Health Sciences Centre
Dallas, Texas, United States
Univeristy of Calgary
Calgary, Alberta, Canada
Endotracheal intubation
Medical procedure in which a tube is placed into the windpipe (trachea) through the mouth.
Time frame: within 30 days of randomization
Mortality
Death
Time frame: 60 days
Invasive mechanical ventilation free days
Number of days not receiving mechanical ventilation
Time frame: censored at 30 Days
Non-invasive ventilation free days
Number of days not receiving non-invasive mechanical ventilation
Time frame: censored 30 days
Days alive and outside ICU
Number of days alive and outside the ICU
Time frame: 60 Days
Days alive and outside of hospital
Number of days alive and outside of hospital
Time frame: 60 days
Complications from proning,
Includes any of the following: accidental removal of intravenous access, hypotension, pressure injuries, or other.
Time frame: 30 days
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
St. Joseph's Healthcare Hamilton
Hamilton, Ontario, Canada
Hamilton General Hospital
Hamilton, Ontario, Canada
Juravinski Hospital
Hamilton, Ontario, Canada
St. Catharine's General -
St. Catharines, Ontario, Canada
Sinai Health System
Toronto, Ontario, Canada
University Health Network - Toronto General Hospital
Toronto, Ontario, Canada
CHU de Québec - Université Laval
Québec, Canada
Al-Amir Hospital
Kuwait City, Kuwait
...and 7 more locations