This study is an observational study to confirm usefulness of a home-based cognitive monitoring in non-demented patients with high-risk of dementia
We prospectively enroll subjects who were diagnosed as mild cognitive impairment based on neuropsychological tests battery, brain MRI, and routine blood labs including thyroid function tests, vitamine B12 \& folate levels, and syphilis screening to rule out other secondary causes of dementia. We undergo peripheral blood-based amyloid beta levels and regular home-based cognitive monitoring (every 3 months) to investigate whether amyloid-positive MCIs progress rapidly using home-based cognitive monitoring during 6 months.
Study Type
OBSERVATIONAL
Enrollment
40
a newly developed home-based cognitive monitoring (about 3-5 minutes per test; total score ranges from 0\~30; higher score indicates better cognition)
Uijeongbu St. Mary's hospital
Uijeongbu-si, South Korea
RECRUITINGhome-based cognitive monitoring score
a 3-5 minutes brief cognitive testing (range 0\~30, higher score means better outcome) using telephone
Time frame: 3 months (at baseline, 3 months from baseline, 6 months from baseline)
Hippocampal atrophy grade
baseline brain MRI markers for hippocampal atrophy using Scheltens' visual rating scale (range 0\~4, higher score means more hippocampal atrophy)
Time frame: at baseline
Number of lacunes
number of lacunes using manual counting on brain MRI (no limit)
Time frame: at baseline
Number of microbleeds
number of microbleeds using manual counting on brain MRI (no limit)
Time frame: at baseline
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