Dry eyes is multi-factorial disease which inflammation play etiological role. Diacerein is drug which has anti-inflammatory effect by antagonist Interleukin-1, decrease Interleukin-1 receptor, increase Interleukin-1 Receptor antagonist. This observational study enrolled participants who going to take diacerein for osteoarthritis, measure corneal staining score, Ocular surface disease index score, Tear Osmolarity, Tear break up time, Schirmer 1 test, Interleukin-1 Receptor antagonist, Interleukin-1 alpha, Interleukin-1 beta level in tear at the time of enrollment and after 2 months.
Study Type
OBSERVATIONAL
Enrollment
34
Diacerein prescribing by orthopedist. Dry eye sign and symptom was asses before start diacerein and after 2 months.
Faculty of medicine, Chulalongkorn university
Bangkok, Thailand
Corneal staining score change from baseline at 2 months
Stain Cornea with Fluorescine, count and score staining at the cornea according to National eye institute : score 0-15 (0=no staining)
Time frame: At the time of enrollment and 2 months
Ocular surface disease index score
Ocular Surface Disease Index : 0-100 (0=no any symptom)
Time frame: At the time of enrollment and 2 months
Tear Osmolarity
Use Tearlab to measure tear osmolarity
Time frame: At the time of enrollment and 2 months
Tear break up time
Stain Cornea with Fluorescine, wait until tear film break, record time that tear break
Time frame: At the time of enrollment and 2 months
Schirmer 1 test
place Schirmer strip at the fornix without anesthesia, wait for 5 min, record tear distance
Time frame: At the time of enrollment and 2 months
Interleukin-1 receptor antagonist, Interleukin-1 alpha, Interleukin-1 beta level in tear
Extract tear from Schirmer strip and use Bioplex for cytokine measurement of Interleukin-1 receptor antagonist(picogram/ml), Interleukin-1 alpha(picogram/ml), Interleukin-1 beta(picogram/ml)
Time frame: At the time of enrollment and 2 months
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