Mortality from Covid-19 increases with age, reaching 14.8% from the age of 80. The severity of the infection is linked to the acute respiratory distress syndrome (ARDS) which requires intensive care. ARDS is the consequence of the reactional inflammatory storm that damages the lungs. Aged subjects are particularly prone to zinc and vitamin D deficiency. These two micronutrients are able to modulate the immune response by reducing the inflammatory storm. The hypothesis is that supplementation with zinc and vitamin D would reduce the inflammatory reaction which worsens ARDS and leads to the death of subjects infected with Covid-19.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Zinc gluconate capsule 15 mg x 2 per day during 2 months
25-OH cholecalciferol drinkable solution 10 drops (2000 IU) per day during 2 months
Survival rate in asymptomatic subjects at inclusion
Time frame: Two months after inclusion
Survival rate in symptomatic subjects at inclusion
Time frame: Two months after inclusion
Survival rate in overall subjects
symptomatic subjects and asymptomatic subjects
Time frame: Two months after inclusion
Cumulative incidence of Covid-19 infection in asymptomatic subjects at inclusion
Time frame: Within two months after inclusion
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