This study aims to investigate immune mechanisms and phenotypes and endotypes of allergic airway diseases - allergic rhinitis and allergic asthma. Pathogenesis of these diseases are not fully investigated yet. Patients with the same disease have different dominant symptoms, course of the disease and response to treatment. Moreover, there is a hypothesis about united airway disease suggesting that allergic rhinitis and allergic asthma is different manifestation of the same disease. This led to assumption of phenotypes and endotypes. This classification which still is not unified can let to prescribe personalized treatment for every patient.
Study Type
OBSERVATIONAL
Enrollment
150
Allergen extract under controlled conditions will be applied into nasal mucous.
Hospital of Lithuanian University of Health Sciences Kauno klinikos
Kaunas, Lithuania
RECRUITINGCytokines level in nasal lavage and peripheral blood after nasal provocation test in different groups.
Cytokines (IL-13, IL-10, IL-22, etc.) level will be measured by ELISA before and after nasal provocation test with house dust mites. Comparison between different groups.
Time frame: 2 hours
Cytokines level in nasal lavage and peripheral blood after nasal provocation test in different groups.
Cytokines (IL-13, IL-10, IL-22, etc.) level will be measured by ELISA before and after nasal provocation test with house dust mites.
Time frame: 22 hours
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