Mechanical ventilation of the patient with acute respiratory distress syndrome is one of the first therapies.
The application of positive end expiratory pressure is recommended but the question remains "How to set the best positive end-expiratory pressure (PEEP) level for each patient? ". Different titration techniques have been studied on oxygenation and respiratory mechanics parameters without reaching a consensus. Currently we have a module that is connected to the ventilator to collect the patient's lung volume. It will therefore allow us to optimize the settings of the ventilator and to set the best level of positive end-expiratory pressure "best peep" in order to individualize our treatment for each patient.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
40
* End expiratory lung volume measurement procedure according to the PEEP level set by the clinician, respecting a Vt at 6ml/kg IBW and Pplat\<28cmH2o * incremental PEEP titration procedure in 5 steps starting from 5cmH2o up to 20cmH2o
Centre Hospitalier Intercommunal Aix-Pertuis
Aix-en-Provence, France
RECRUITINGObserve end-expiratory lung volume change during an increasing PEEP titration procedure in patients with moderate to severe ARDS
Time frame: 1 day
Define a threshold of end-expiratory lung volume variation to help determine optimal PEEP
Time frame: 1 day
Analyzing the effect of PEEP titration on static compliance and dynamic strain
Time frame: 1 day
Effect of PEEP titration on hematosis via the calculation of the Pao2/Fio2 ratio for each PEEP step thanks to the measurement of Pao2 on arterial gasometry
Time frame: 1 day
Study the correlation between % change in end-expiratory lung volume and improvement in hematosis (Pao2/Fio2)
Time frame: 1 day
Compare end-expiratory lung volume variations according to the type of ARDS (severity, focal or diffuse, pulmonary or extra-pulmonary etiology)
Time frame: 1 day
Evaluate the hemodynamic tolerance of this procedure with the mean arterial pressure obtained by invasive blood pressure, noradrenaline dosage variation per procedure, lactate (obtained by arterial blood gas)
Time frame: 1 day
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