Given the current lack of effective COVID-19 treatment, it is necessary to explore alternative methods to contain the spread of the infection, focusing in particular on its mode of transmission. The modes of person-to-person transmission of SARS-CoV-2 are direct transmission, such as sneezing, coughing, transmission through inhalation of small droplets, and transmission through contact, such as contact with nasal, oral and eye mucous membranes. SARS-CoV-2 can also be transmitted directly or indirectly through saliva. The use of antiviral mouthrinses may be used as adjunctive therapy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
176
3 daily mouthrinses for 7 days
3 daily mouthrinses for 7 days
Clinic of the Protestant Infirmary in Lyon
Caluire-et-Cuire, France
Hospital Center Emile Roux
Le Puy-en-Velay, France
Hospital Center Saint Luc Saint Joseph
Lyon, France
Intercommunal Hospital Center of Mont de Marsan
Mont-de-Marsan, France
Change from Baseline amount of SARS-CoV-2 in salivary samples at 7 days
Quantitative PCR experiments will be performed and a quantitative analysis of the salivary samples will be made
Time frame: 7 days
Change from Baseline amount of SARS-CoV-2 virus in nasal samples at 7 days
Quantitative PCR experiments will be performed and a quantitative analysis of the nasal samples will be made
Time frame: 7 days
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