The purpose of this investigator-initiated study is to evaluate the effects of oral curcumin supplementation versus placebo in adult patients with moderate to severe asthma. Curcumin, a derivative of turmeric, has been shown in animal models to inhibit the secretion of pro-inflammatory cytokines and decrease airway constriction and hyperreactivity with only a few observational studies available in humans with discordant results.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Asthma Control
defined by the Asthma Control Test, which has a 5-point scale (for symptoms and activities: 1=all the time to 5= not at all; for asthma control rating: 1=not controlled at all to 5=completely controlled)
Time frame: 3 months
Number of Severe Asthma Exacerbations in 3 Months
Time frame: 3 months
Cumulative Days Missed From School or Work in 3 Months
Time frame: 3 months
Spirometry
FEV1/FVC ratio, FEV1: forced expiratory volume in one second, FVC: forced vital capacity
Time frame: 3 months
Exhaled nitric oxide
Time frame: 3 months
Total IgE
Time frame: 3 months
Total plasma eosinophil count
Time frame: 3 months
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