Observational case-control study in a retrospective cohort of patients with stage II or III colorectal cancer undergoing scheduled surgery.
Observational case-control study in a retrospective cohort of patients with stage II or III colorectal cancer undergoing scheduled surgery. Period January 2010-December 2014. Patients must have had at least 5 years of follow-up to define disease-free survival. From the cohort of patients previously studied in our center by immunohistochemistry, 31 we will select 10 cases with recurrence by random sampling and we will match 10 controls by leveling the propensity score (propensity score matching).
Study Type
OBSERVATIONAL
Enrollment
20
Assess the difference in the quantitative expression of MOR-1 (by means of RT-qPCR) between healthy tissue and tumor tissue, in patients with stage II and III colorectal cancer undergoing scheduled surgery.
MOR-1 expression by polymerase chain reaction (RT-qPCR) in tumor tissue and adjacent healthy tissue.
Time frame: Day 1
Cancer-free survival 5 years after surgery (disease-free survival-DFS).
Time frame: Day 1
Degree of MOR-1 activation measured by immunohistochemistry through cAMP and PKA levels.
Time frame: Day 1
MOR-1 expression by immunohistochemistry in tumor tissue and adjacent healthy tissue.
Time frame: Day 1
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