Capnography Monitoring in Ventilated Children

Vincenzo Cannizzaro178 enrolled

Overview

End-tidal CO2 measurements in children will be assessed for their accuracy with arterial CO2 measurements.

End-tidal and arterial CO2 measurements will be performed in invasively and non-invasively ventilated critically ill children. The endtidal CO2 values will assessed for their accuracy with respect to different underlying diseases and conditions of the children.

Study Type

OBSERVATIONAL

Enrollment

178

Conditions

Child, Only Infant, Newborn, Diseases Critical Illness ARDS, Human Heart Defects, Congenital Lung Diseases, Obstructive Lung Diseases, Interstitial

Interventions

capnography monitoringDIAGNOSTIC_TEST

routinely used capnography monitoring

arterial blood gasDIAGNOSTIC_TEST

Routinely taken arterial blood gas values

Eligibility

Sex: ALLMin age: 1 HourMax age: 13 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Children on pressure controlled mechanical invasive or non-invasive ventilation on the Paediatric Intensive Care Unit of the University Children's Hospital Zurich * Newborns with a birthweight of at least 2.0 kg * Newborns with an age of at least 1 hour (age \> 60 minutes) * Children up to the last day of the 13th year of living * Ability of care taker or patient to understand verbal and written instructions and the general consent or informed consent in German or English * Obtained written general or informed consent as documented by signature * Available arterial line, i.e. a specific catheter inserted in an artery Exclusion Criteria: * Care taker or participant unable for linguistic, mental or other reasons or unwilling to understand verbal or written information and to give written informed consent in German or English * Care taker not available * Newborns with a birthweight below 2.0 kg * Newborns younger than 1 hour (age \<60 minutes) * Children with an age of 14 years onwards * Missing arterial line * Patients dependent on any other kind of respiratory support that is not compatible with the PcCO2-sensor or where a high leakage in the respiratory circuit makes PcCO2 measurements impossible (nasal mask ventilation, low-flow-/high-flow-ventilation, rebreathing mask, high- frequency-oscillation) * Patients where the investigators act on the assumption that mechanical ventilation will be discontinued and/or the arterial line will be removed within 6 hours or where only one pair of values (arterial and endtidal CO2) can be compared * Patients with a cyanotic shunt lesion with a weight of 15 kg or above

Locations (1)

University Children's Hospital

Zurich, Switzerland

Outcomes

Primary Outcomes

Accuracy of end-tidal Carbon Dioxide (PetCO2) values in comparison to arterial Carbon Dioxide (PaCO2) values in invasively and non-invasively ventilated critically ill children without lung or heart disease

Mean absolute measurement difference between simultaneously obtained PaCO2 and PetCO2 values (bias) and their 95% limits of agreement (precision) in children and newborns without cardiopulmonary dysfunction. Units of measure will be in kilopascal (kPa) for PetCO2 and PaCO2, respectively.

Time frame: On average every participant will be assessed for 5 days

Secondary Outcomes

Cardiopulmonary function-dependent mean absolute measurement difference between simultaneously obtained PaCO2 and PetCO2 values (bias) and their 95% limits of agreement (precision) in children and newborns with cardiopulmonary dysfunction. Units of measure will be in kilopascal (kPa) for PetCO2 and PaCO2, respectively.

Time frame: On average every participant will be assessed for 5 days

Data from ClinicalTrials.gov

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