The study was aimed at investigating the relationship between hormone parameters and urinary aldosterone levels in 24h within a cohort of overweight and obesity.
Subjects were enrolled at the first examination whether they were not taking any medication, including oral contraceptives or drugs for osteoporosis, and free of significant medical illnesses, except obesity. Exclusion criteria were history of endocrinological diseases (diabetes mellitus, hypo or hyperthyroidism, hypopituitarism, etc.), chronic inflammatory diseases, stable known hypertension, angina pectoris, stroke, transient ischemic attack, heart infarction, congenital heart disease, malignancies, chronic inflammatory diseases, renal and liver failure, angina pectoris, myocardial infarction, heart failure, congenital heart diseases, minor and major stroke, and inherited thrombocytopenias and other major malignancies. Subjects were examined by means of the medical history, hormonal, metabolic and routine hematochemical parameters. The investigators provided for a clinical baseline evaluation that included extemporaneous ambulatory blood pressure (BP) and a physical assessment of body weight, Body Mass Index (BMI) and Waist Circumference (WC) as anthropometric parameters.
Study Type
OBSERVATIONAL
Enrollment
230
Observational
National Institute of Gastroenterology IRCCS S. de Bellis
Castellana Grotte, Bari, Italy
Thyroid hormones (FT3, FT4)
FT3 (pg/mL), FT4 (pg/mL) concentration in serum
Time frame: Baseline
TSH
TSH (mU/L) concentration in serum
Time frame: Baseline
Urinary Aldosterone
24-h Urine Aldosterone (mg/24 h)
Time frame: Baseline
Prolactin
Prolactin (ng/ml) concentration in serum
Time frame: Baseline
Insulin
Insulin (mIU/L) concentration in serum
Time frame: Baseline
Parathyroid Hormone
PTH (pg/mL) concentration in serum
Time frame: Baseline
Total cholesterol
Total cholesterol (mg/dL) concentrations in serum
Time frame: Baseline
HDL cholesterol
HDL cholesterol (mg/dL) concentrations in serum
Time frame: Baseline
LDL cholesterol
LDL cholesterol (mg/dL) concentrations in serum
Time frame: Baseline
BMI
BMI (kg/m\^2)
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Time frame: Baseline
Height
Height in meters
Time frame: Baseline
Weight
Weight in kilograms
Time frame: Baseline
Vitamin D
Vitamin D (ng/mL) concentration in serum
Time frame: Baseline