The aim of the study is to understand the impact of COVID-19 on People with Multiple Sclerosis in the United Kingdom.
Study objectives 1. To identify the incidence of upper respiratory tract symptoms: fever, cough and breathing difficulties, other symptoms suggestive of COVID-19 infection, respiratory tract infections suggestive of COVID-19, and COVID-19 confirmed by laboratory testing among the UK MS population 2. To establish if some DMDs increase the risk of COVID-19 infection 3. To determine the incidence and effectiveness of self-isolation in the MS population. To examine the impact self-isolation has on mood, fatigue, and other routinely collected patient reported outcome measures from the MS Register. 4. To determine the clinical outcome of respiratory tract infections, including confirmed and suspected cases of COVID-19, in terms of symptoms, time to recovery, hospital admission, requirement for ventilation, and death. 5. To determine the longer-term impact of COVID-19 on MS, using routinely collected MS outcomes in the MS register, including impact on disability, relapses and changes in DMDs as assessed at 3 monthly intervals. 6. To determine where people are obtaining their health information during the COVID-19 outbreak. 7. To establish changes in DMDs prior to and as a result of symptoms related and unrelated to COVID-19
Study Type
OBSERVATIONAL
Enrollment
3,000
Swansea Univeristy
Swansea, United Kingdom
Incidence of COVID-19 Infections within an MS Cohort in the UK
Targeted questionnaire dependent on COVID Status
Time frame: Through study completion, an average of 1 year
Hospitalisations in MS Patients with COVID-19
Monitor admission rates in linked population
Time frame: 1 Year (regular outputs)
Mortality
Death data from routinely reported government level data (HES/PEDW)
Time frame: 1 Year from study commencement
Patient Reported Expanded Disability Status Score
Patient Reported Outcome for MS disability
Time frame: 1 year (at least 6 monthly)
Hospital Anxiety and Depression Scale
Patient Reported Outcome for anxiety and depression
Time frame: 1 year (at least 6 monthly)
Multiple Sclerosis Impact Scale 29 V2
Patient Reported Outcome for Multiple sclerosis impact on physical and psychological status
Time frame: 1 year (at least 6 monthly)
Multiple Sclerosis Walking Scale 12 V2
Patient Reported Outcome for walking status
Time frame: 1 year (at least 6 monthly)
Fatigue Severity Scale
Patient Reported Outcome for impact of fatigue
Time frame: 1 year (at least 6 monthly)
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EuroQol 5D (3l)
Patient Reported Outcome for general quality of life
Time frame: 1 year (at least 6 monthly)