Qualitative and Quantitative Evaluation of Anosmia Over Time in Clinically Symptomatic Patients Tested for COVID-19 Infection

Centre Hospitalier Universitaire de Nīmes454 enrolled

Overview

Loss of sense of smell and taste has been anecdotally reported during the covid-19 epidemic. The study investigators wanted to describe the prevalence of olfactory and gustatory dysfunction and assess the factors associated with positive SARS-CoV-2 infection.

Study Type

OBSERVATIONAL

Enrollment

454

Conditions

COVID-19

Interventions

olfactory and gustatory testsOTHER

Participants rate quality of sense of smell and taste. Olfaction test: Sniff 10ml test tube containing 1.5ml air freshner (Mifleur Citron, Coldis, Entraigues sur Sorgues, France) and rate perception of odor. Gustatory test: Taste a pinch and sugar and salt and rate perception of sweet or salty taste

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients presenting with COVID-19 related symptoms including: fever, persistent cough, fatigue, shortness of breath, diarrhoea, abdominal pain, chest pain, sore throat, loss of smell or taste * Subjects in prolonged contact with COVID-19 infected patients. Exclusion Criteria: * Patients directly admitted to the intensive care unit were excluded * Patients opposing use of their health data

Locations (1)

CHU de Nimes

Nîmes, France

Outcomes

Primary Outcomes

SARS-CoV-2 infection status

Positive/negative according to RT-PCR assay

Time frame: Day 0

Olfactory and gustatory loss

Custom-designed questionnaire (28 questions pertaining to symptoms, sense of smell and taste)

Time frame: Day 0

Secondary Outcomes

Ability to detect odor

Ability to smell 1.5ml air freshner on a 0-100 VAS scale

Time frame: Day 0

Ability to detect odor

Ability to smell 1.5ml air freshner on a 0-100 VAS scale

Time frame: Six months

Ability to detect salty taste

Ability to taste a pinch of table salt on a 0-100 VAS scale

Time frame: Day 0

Ability to detect salty taste

Ability to taste a pinch of table salt on a 0-100 VAS scale

Time frame: Six months

Ability to detect sweet taste

Ability to taste a pinch of sugar on a 0-100 VAS scale

Time frame: Day 0

Ability to detect sweet taste

Ability to taste a pinch of sugar on a 0-100 VAS scale

Time frame: Six months

Olfactory and gustatory loss

Custom-designed questionnaire (28 questions pertaining to symptoms, sense of smell and taste)

Data from ClinicalTrials.gov

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