A Study of Naldemedine in Participants Undergoing Surgeries That Include a Bowel Resection or Bowel Transection

Inclusion Criteria: * Scheduled to undergo 1 of the following procedures via open (nonlaparoscopic) surgery under general anesthesia: * partial small or large bowel resection with primary anastomosis * radical cystectomy requiring bowel transection with primary anastomosis * Planned to be managed postoperatively with an enhanced recovery protocol, which, at a minimum, includes all of the following elements: * early removal of the nasogastric tube, which is defined as removal of the nasogastric tube at the end of surgery * early ambulation, which is defined as ambulation on Day 1 * early diet advancement on Day 1 * Planned to receive primary postoperative pain management with opioid analgesia administered by any route. * American Society of Anesthesiologists (ASA) Physical Status Score of I, II, or III (a normal healthy participant, a participant with mild systemic disease, and a participant with systemic disease, respectively). Exclusion Criteria: * Scheduled to undergo a total colectomy or any procedure that results in a colostomy or ileostomy. * Scheduled for endoscopic or laparoscopic surgery. * Complete bowel obstruction. * Complicated inflammatory bowel disease (such as ulcerative colitis or Crohn's disease). * More than 2 major abdominal surgery (for example, gastrectomy, gastric bypass, gastric sleeve, lap banding, pancreatic resection, hepatectomy, intestinal transplant). * More than 3 doses of an opioid (regardless of the route of administration) during the 7 days prior to surgery. * Pregnancy or lactation. * Presence of peritoneal catheter (for example, for dialysis or chemotherapy).