Heparin diluent or normal saline is generally used as the arterial tube flushing in clinical practice, but there is no consensus on the choice of flushing fluid. Heparin can affect the blood coagulation function, and even lead to heparin-related thrombocytopenia, increasing the risk of perioperative embolism. Sonoclot is a blood viscoelasticity test, which can provide comprehensive information on the coagulation's cascade and the entire process and be quicker and more effective than routine laboratory coagulation tests. In this research, the coagulation and platelet function analyzer called Sonoclot is used to evaluate the effect of different concentrations of pressurized heparin on the coagulation and platelet function of perioperative patients, which can provide a reference for the clinical choice of appropriate arterial flushing.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
60
heparin with a concentration of 2 U/ml is used for pressurized continuous flushing of the invasive arterial pressure monitoring tube
heparin with a concentration of 4 U/ml is used for pressurized continuous flushing of the invasive arterial pressure monitoring tube
normal saline is used for pressurized continuous flushing of the invasive arterial pressure monitoring tube
the Affiliated Hospital of Yangzhou University, Yangzhou University
Yangzhou, Jiangsu, China
The level of glass bead Activated Clotting Time
10 min after the vein puncture, 2 h after skin incision and at the end of surgery
Time frame: through study completion, an average of 3 minute
The level of glass bead Clot Rate
10 min after the vein puncture, 2 h after skin incision and at the end of surgery
Time frame: through study completion, an average of 3 minute
The level of glass bead Platelet Function
10 min after the vein puncture, 2 h after skin incision and at the end of surgery
Time frame: through study completion, an average of 3 minute
The level of platelet count
24 h after surgery and 48 h after surgery
Time frame: through study completion, an average of 2 minute
The frequencies of hand positional changes and manual artery flushing
Time frame: intraoperative
The amount of infusion volume, blood loss, urine volume
Time frame: intraoperative
The appearance of local complications of arterial puncture
Yes or No
Time frame: within 24 h after surgery
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