Although preliminary evidence suggests that intermittent fasting mimic-diet (IFD) exerts stronger effects on body weight and metabolic parameters, which may link obesity, non-alcoholic fatty liver disease (NAFLD) and major chronic diseases, compared with continuous calorie restriction (CCR), there is a lack of well-powered intervention studies. This randomized controlled trial will test whether IFD, operationalized as the "5:2 diet," has stronger effects on anthropometric and body composition characteristics, and circulating metabolic biomarkers than CCR and a control regimen in adults with NAFLD.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
120
Participants randomized to IFD were asked to restrict energy and carbohydrate on two non-consecutive days each week (75% energy restriction) and to consume a plant foods-based diet that met their estimated energy requirements for the remaining 5 d of the week. The CCR group was prescribed a daily plant foods-based diet that was relatively low in fat with moderate energy-restriction (25% energy restriction). The plant foods-based diet included adequate fruit and vegetable, nuts and seeds, whole-grain cereals, olive oil, fish and seafood, a moderate consumption of dairy products, poultry, eggs, and lean red meat.
Guangdong Medical University
Dongguan, Guangdong, China
RECRUITINGBody weight
Change of body weight
Time frame: Change from baseline body weight at week 8
Lipid profile
Plasma lipids levels
Time frame: Change from baseline plasma TG, TC and LDL at week 8
Insulin resistance
Plasma glucose and insulin levels
Time frame: Change from baseline plasma glucose and insulin at week 8
Gut microbiota
Changes of blood metabolites and the gut microbiome
Time frame: Change from baseline plasma bile acids and the gut microbiome at week 8
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