Trial of COVID-19 Outpatient Treatment in Individuals With Risk Factors for Aggravation

Inclusion Criteria: * Clinical picture suggestive of COVID-19 dated 7 days or less. * Positivity of a test proving an acute SARS-CoV-2 infection, according to current recommendations. * Absence of criteria for hospitalization or oxygen therapy according to current recommendations. * Age : * greater than or equal to 60 years of age without any risk factor * or between 50 and 59 years of age and the presence of at least one of the following risk factors : * Arterial hypertension under treatment (all stages) * Obesity (BMI ≥30 kg/m2) * Diabetes under treatment (all types) * Ischemic heart disease (all stages) * Heart failure (all stages) * Stroke History * Chronic Obstructive Pulmonary Disease (all stages) * Stage 3 chronic renal failure (30 ≤ Estimated GFR \< 60 mL/min/1.73 m²) * Malignancies (solid tumours or blood malignancies) that are progressive or were diagnosed less than 5 years ago. * Immunodeficiency * of therapeutic origin (solid organ transplant or hematopoietic stem cell transplant, cancer chemotherapy, immunosuppressive therapy, corticosteroids \> 15 mg/d of prednisone equivalent taken for at least 2 months); * HIV infection with CD4\<200/mm3. * Valid, ambulatory person, fully able to understand the issues of the trial * Beneficiary of a Social Security scheme * Signed informed consent Exclusion Criteria: * Asymptomatic person * Inability to make a decision to participate (dementia, person under legal protection, curatorship or guardianship) * Ongoing illness or chronic treatment contraindicated by taking one of the trial drugs.