COVID-19: A Pilot Study of Adaptive Immunity and Anti-PD1

Inclusion Criteria: * Diagnosis of COVID-19 by RT-PCR for SARS-CoV-2 * Clinically stable with disease severity defined as mild or moderate (mild disease is defined as symptoms with or without lung infiltrates on chest X-Ray or CT imaging; moderate disease is defined as lung infiltrates with evidence of type 1 respiratory failure) * Asymptomatic patients may be enrolled if patients have obvious radiographic changes on chest or CT radiography deemed to be related to COVID-19 Exclusion Criteria: * Active cancer, rheumatological and autoimmune conditions * Transplant recipients, or patients on active immunosuppressants * Chronic organ impairment, or documented or suspected concomitant infections (including chronic viral hepatitis B and hepatitis C) other than SARS-CoV-2 * Lactating mothers and women who are pregnant or intending to become pregnant * Acute respiratory distress syndrome, evidence of myocardial injury, disseminated intravascular coagulopathy, organ failure, hemophagocytosis, shock, respiratory distress, or need for mechanical ventilation, AICU admission, or high flow oxygen therapy