This study evaluates the addition of dapagliflozin in the treatment of type 2 diabetes with metformin and evogliptin combination therapy. Half of subjects will receive dapagliflozin, metformin and evogliptin, while the other half will receive placebo, metformin and evogliptin.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
198
Dapagliflozin 10mg, orally, once daily, up to 24weeks
Dapagliflozin Placebo, orally, once daily, up to 24weeks
Evogliptin 5mg, orally, once daily for background therapy
The Catholic University of Korea Bucheon St. Mary's Hospital
Bucheon-si, South Korea
Change from the baseline in HbA1c (%) after 24 weeks
Time frame: Baseline, 24 weeks
Change from the baseline in fasting plasma glucose(mg/dL) after 24 weeks
Time frame: Baseline, 24 weeks
Change from the baseline in HbA1c response rate(<7.0%, <6.5%) after 24 weeks
Time frame: Baseline, 24 weeks
Change from the baseline in weight after 24 weeks
Time frame: Baseline, 24 weeks
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Metformin≥1000mg, orally, daily for background therapy