The outbreak at covid-19 is caused by the SARS-CoV-2 virus. This virus can be responsible for severe respiratory failure but also for extra-respiratory organ dysfunctions associated with severe inflammatory stress. The endothelium is an important structure of the blood vessels and is implicated in the organ failure of many patients admitted in intensive care units. It could be affected by the virus and its alteration may explain the organ dysfunction of covid-19 ICU patients as well as the thrombotic processes frequently obstructed in this infection.
Study Type
OBSERVATIONAL
Enrollment
100
Rouen University Hospital
Rouen, France
RECRUITINGAssociation of InterCellular Adhesion Molecule-1 plasma level with 28 days mortality
Plasma of covid-19 patients will be tested for endothelial injuries, notably with the measurement of InterCellular Adhesion Molecule 1 level by Enzym-Linked Immunosorbent Assay. The association of these levels with 28-days mortality will be evaluated as prognosis markers.
Time frame: 24 hours
Association of Endothelin-1 plasma level with 28 days mortality
Endothelin-1 will be assessed in blood as a maker of endothelial injuries, expressed in pg/mL. its association with 28 -days mortality will be evaluated.
Time frame: 24 hours
Association of Vascular Endothelial Growth Factor A plasma level with 28 days mortality
Vascular Endothelial Growth Factor A plasma level will be measured in blood as a marker of endothelial injury expressed in pg/mL. its association with 28 -days mortality will be evaluated.
Time frame: 24 hours
Association of soluble Vascular Endothelial Growth Factor Receptor type 1 with 28 days mortality
This soluble receptor is another marker of endothelial injury and will be measured in blood and expressed as pg/mL. Its association with 28-days mortality will be evaluated.
Time frame: 24 hours
Association of syndecan -1 plasma level with 28 days mortality
syndecan -1 is a marker of degradation of glycocalyx, raised during endothelial injury. It will be measured in blood and expressed as pg/mL. Its assocation with 28-days mortality will be evaluated.
Time frame: 24 hours
Association of D-dimers plasma levels with thrombotic events
D-dimers si marker of enhanced thrombotic activity. It may be increased during covid-19 disease but its correlation with endothelial injury is not known. It will be measured in blood and expressed as microgrammes/L, and then correlated with ICAM-1 plasma levels
Time frame: 24 hours
Association of von Willebrandt Factor with thrombotic events
This marker may be raised during endothelial injury and may explained thrombotic status of covid-19 patients. Its blood levels will be measured and expressed as international unit/dL, and correlated with ICAM-1 plasma levels
Time frame: 24 hours
Association of Viscoelastic testing with thrombotic events
Clot Stiffness and its fibrinogen and platelet contributions (expressed in kPa) will be measured as novative approach, using Quantra (Stago Inc) device, to explore hemostasis alterations of covid-19 patients.
Time frame: 24 hours
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