Clinical Trial of Sarilumab in Adults With COVID-19

Inclusion Criteria: * Age ≥ 18 years and \<75 years * Admission for confirmed respiratory symptoms to COVID-19 based on a positive PCR in a sample of the respiratory tract in the local laboratory in the absence of respiratory distress syndrome requiring ONAF or mechanical ventilation * Interstitial pneumonia confirmed by chest radiography or CT * IL-6 levels\> 40 pg / ml. In its absence, D-Dimer (DD)\> 1500 or\> 1000 may be included if progressive increases are documented * Negative pregnancy test in women of childbearing age * Signature of informed consent Exclusion Criteria: * SOFA score\> 6 points * Patient who, in the researcher's opinion, is not a subsidiary of invasive mechanical ventilation * Neutrophil count \<2 x 103 / μL * Platelet count \<100 x 103 / μL * ALT or AST levels\> 5 times the upper limit of normal * Severe renal failure (CrCr \<30 ml / min) * Active bacterial infectious process * Active tuberculosis, history of not completing treatment against tuberculosis, suspicion of extrapulmonary tuberculosis * History of intestinal ulcer or diverticulitis * History of hypersensitivity reactions to Sarilumab or its excipients * Treatment with TNF antagonists * Previous treatment with anti-IL6 in the previous 30 days * Chronic prior treatment with corticosteroids at doses greater than 0.5 mg / kg / day of prednisone or equivalent. Yes, inhaled and topical corticosteroids are acceptable * Concomitant treatment with immunomodulators, among which are Vitamin D or statins. Macrolides such as azithromycin are acceptable * Patients on immunosuppressive treatment for any cause * HIV-infected patients with CD4 \<200 / mm3 * Past or current history of autoimmune disease or systemic inflammatory disease * Patients who have received or are planning therapy with immunomodulatory antibodies, including immunoglobulins * Participation in any clinical trial that evaluated any investigational product in the last 3 months or less than 5 half-lives of the investigational product * Pregnancy * Any other condition that, in clinical judgment, prevents adherence to the patient's protocol