The investigators studied the renal function index level in terlipressin treated cirrhotic patients with upper-gastrointestinal bleeding at different time point.
54 cirrhotic patients with uppre-gastrointestinal bleeding were entrolled and were distributed into terlipressin group and control group at 1:1 rate. Patients in Terlipressin group received 1mg/6h of terlipressin intravenously for 5 days, and patients in control group recerved 1mg/12h of Somatostatin intravenously for 5 days. At enrollment, 24h,48h,72,and 1week, the renal function index level( serum creatinine,urine biochemistry and Urinary tubule injury index etc) were tested.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
54
Evaluate the effect of Terlipression on the occurance of acute kidney injury in patients with upper-gastroentestinal bleeding
Somatostatin
Changhai hospital
Shanghai, China
incidence of acute kidney injure
serum creatinine level increased by 26.5umol/L during 48hours or increased 50% compared to baseline
Time frame: 48 hours
hemostasis rate
Fecal occult blood negative or hemoglobin stable after 48H treatment
Time frame: 48 hours
incidence of hepatic encephalopathy
Increased blood ammonia or directional force and computational power decrease after 48H treatment
Time frame: 48 hours
The incidence of spontaneous bacterial peritonitis;
After 48H treatment, there is ascites and ascites has more than 20% nuclear cells
Time frame: 48 hours
The incidence of hyponatremia
Serum sodium levels below 130mmol/l
Time frame: 48 hours
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.