Rhu-pGSN for Severe Covid-19 Pneumonia

Inclusion Criteria: * Hospitalized with laboratory-confirmed (RT-PCR+) or highly suspected (compatible with at least bilobar lung involvement without another plausible diagnosis) COVID-19 * Weight ≤100 kg * Within 24 hours of reaching a WHO severity score of 4-6 either: * At admission * While already hospitalized * Informed consent obtained from subject/next of kin/legal proxy * Primary admitting diagnosis of pneumonia supported by a compatible clinical presentation with a documented infiltrate consistent with pneumonia on chest radiograph or CT as assessed by the admitting emergency-department (ED), clinic, or ward physician or equivalent caregiver * Recommended (not mandatory) guidance/discretionary criteria defining patients with pneumonia satisfying all 4 categories below: * At least 2 symptoms: difficulty breathing, cough, production of purulent sputum, or chest pain * At least 2 vital sign abnormalities: fever, tachycardia, or tachypnea (thresholds -- fever: oral or core temperature \>100.4 °F \[38 °C\]; heart rate \>100 beats/min; respiratory rate \>24/min) * At least one finding of other clinical signs and laboratory abnormalities: hypoxemia (O2 saturation \<90%), clinical evidence of pulmonary consolidation, or leukocytosis or leukopenia * Chest imaging or CT showing new (or presumed new or worsening) pulmonary infiltrates * Principal investigator to note radiologic findings in the electronic case report form (eCRF) * Radiology report to be placed in the eCRF * A copy of the radiograph attached to be saved for review * A hyperinflammatory status (defined by increased ferritin ≥500 µg/L, D-dimer ≥1000 ng/mL, or C-reactive protein (CRP) ≥75 mg/L) * During the course of the study starting at screening and for at least 6 months after their final study treatment: * Female subjects of childbearing potential must agree to use 2 medically accepted birth control methods * Male subjects with a partner who might become pregnant must agree to use reliable forms of contraception (i.e., vasectomy, abstinence), or an acceptable method of birth control must be used by the partner * All subjects must agree not to donate sperm or eggs (ovocytes) Exclusion Criteria: * A negative RT-PCR test for COVID-19 during the evaluation of the present illness * Extracorporeal membrane oxygenation (ECMO) * Pregnant or lactating women * Active underlying cancer treated with systemic chemotherapy or radiation therapy during the last 30 days * Transplantation of hematopoietic or solid organs * Chronic mechanical ventilation or dialysis * Otherwise unsuitable for study participation because of chronic, severe, end-stage, and life-limiting underlying disease unrelated to COVID-19 likely to interfere with management and assessment of acute pneumonia, only comfort or limited (non-aggressive) care is to be given, or life expectancy \<6 months unrelated to acute COVID infection in the opinion of the Investigator