Gefitinib With Anlotinib in Advanced Non-squamous NSCLC Patients With Uncleared Plasma ctDNA EGFRm After First-line Treatment With Gefitinib

Inclusion Criteria: * Histologically confirmed that EGFR sensitive mutation (ex19del or L858R mutation) in tumor tissue was detected by non-squamous NSCLC, and EGFR mutation (ex19del or L858R mutation) in ctDNA before treatment; * Staging is IVB stage (AJCC 8th Edition) ; * According to the comprehensive judgment of many disciplines, it is impossible to be treated by operation; * PS score 0-1; * The patient has at least one measurable tumor injury (the tumor is considered unmeasurable at the site of previous radiotherapy); * Systemic anti-tumor therapy such as chemotherapy, immunotherapy and targeted therapy were not performed before entering the group; * There is no history of malignant tumor and no serious medical disease; * FEV1 ≥ 1.2L/ seconds or ≥ 50% predicted value; * Laboratory examination: White blood cell count ≥ 4 \*10\^9/L, neutrophil count ≥ 2.0 \*10\^9, platelet count ≥ 100 \*10\^9, hemoglobin ≥ 10 g / L, liver and kidney function and ECG were normal; * The pregnancy test was negative within 3 days before entering the group, and agreed to use medically effective contraceptive measures during the trial; * Life expectancy is more than 12 weeks; * Sign informed consent form; cooperate with regular follow-up. Exclusion Criteria: * T4 (AJCC 8th Edition) patients with severe destruction and stenosis of large vessels confirmed by imaging; * Clinical severe infection (\> grade 2 NCI-CTC V3.0); * Severe immunosuppressive disease; * The patient's physical condition is life-threatening; * A pregnant or breastfeeding patient. Female patients who are likely to become pregnant must be tested negative within 7 days of the start of treatment before continuing. Patients enrolled in the trial (both male and female) must use contraception during the trial period until two weeks after the trial is completed; * PS score ≥ 2; * At the same time, there are other serious diseases (congestive heart failure, transmural myocardial infarction, COPD or other respiratory diseases that affect treatment, etc.), considering that the study may aggravate or fail to control the disease; * Those who have suffered or are currently suffering from tumors whose primary site or histology are different from those evaluated in this study. Excluding cervical carcinoma in situ, cured basal cell carcinoma, bladder surface tumor \[Ta,Tis\&T1\], or any cured tumor that has been in the study for more than 3 years; * The patient refused to participate.