Elastography is a new non-invasive medical technique for measuring the stiffness at a distance from a tissue. Recent advances in the development of elastography sequences for cardiac exploration suggest a more clinical approach to cardiac elastography. This study propose to compare myocardial stiffness of a group of coronary bypass patients without hypertrophic left ventricular remodeling or sequelae of myocardial infarction versus a group of patients who should benefit from a surgical aortic valve replacement for aortic stenosis. The hypothesis is that the physiological adaptation to pressure overload constituted by aortic stenosis is responsible for a significant increase in myocardial stiffness compared to a reference group.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
98
To measure myocardial stiffness by ShearWave elastography on not beating heart
CHU Caen
Caen, France
CHU de Rouen
Rouen, France
to compare myocardial stiffness by ShearWave elastography on not beating heart in two groups of patients referred for surgery
The main outcome measure is evaluated by ShearWave elastography with the measurement of Young modulus on non-beating heart
Time frame: Day 1
To compare the diastolic myocardial stiffness of the beating heart with the myocardial stiffness of the non-beating heart
This outcome measure is evaluated by ShearWave elastography with the measurement of Young modulus on non-beating heart
Time frame: Day 1
To compare epicardial and trans-thoracic diastolic myocardial stiffness
This outcome measure is evaluated by elastography using the measurement of Young modulus in epicardial (using the linear probe) and transthoracic (using the scanning probe).
Time frame: Day 1
Correlation between the diastolic myocardial stiffness of the beating heart and the non-beating heart with conventional diastolic indices
This outcome measure is evaluated: 1. by ShearWave elastography with the measurement of Young modulus on non-beating heart 2. by conventional ultrasound criteria (peak e', peak E, volume of the left atrium calculated by simpson biplanes, maximum velocity of tricuspid insufficiency).
Time frame: Day 1
Correlation between the diastolic myocardial stiffness of the beating heart and the non-beating heart with heart failure parameters
This outcome measure is evaluated: 1. by ShearWave elastography with the measurement of Young modulus on non-beating heart 2. by heart failure parameters defined by NYHA class, the walking test and the BNP assay
Time frame: Day 1
Correlation between the diastolic myocardial stiffness of the beating heart and the non-beating heart with left ventricular mass indexed to the body surface
This outcome measure is evaluated: 1. by ShearWave elastography with the measurement of Young modulus on non-beating heart 2. by LV mass indexed to the body surface calculated by the cardiac mass measuring by ultrasound indexed to the body surface
Time frame: Day 1
Correlation between the diastolic myocardial stiffness of the beating heart and the non-beating heart and the prognosis
This outcome measure is evaluated: 1. by ShearWave elastography with the measurement of Young modulus on non-beating heart 2. by a combined index combining all rehospitalization for heart failure, increase in heart failure treatment and cardiac death
Time frame: 1 year
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