Multiple lines of evidence have shown that perioperative opioids requirement was associated with poor outcomes in cancer patients, including increased cancer progression and metastases and reduced survival in patients with lung, breast, prostate, and bladder cancer. Circulating tumor cells (CTCs) have been validated as prognostic biomarkers of a number of cancers. The aim of this study is to investigate the effects of perioperative opioids on the number of CTCs in patients receiving robot-assisted laparoscopic radical cystectomy. The difference of the amounts of perioperative opioids is achieved by using general anesthesia combined with intravenous opioid-based analgesia intra- and post-operatively in one group and general analgesia combined with epidural ropivacaine-based analgesia in the other group.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
44
Patients will receive intraoperative and postoperative intravenous opioid-based analgesia for robot-assisted laparoscopic radical cystectomy.
Patients will receive epidural ropivacaine-based analgesia for robot-assisted laparoscopic radical cystectomy.
Renji hospital, School of Medicine, Shanghai Jiaotong University
Shanghai, Shanghai Municipality, China
the number of circulating tumor cells
The number of circulating tumor cells will be measured by collecting 5ml of venous blood sample.
Time frame: on the 3rd day after surgery
the number of circulating tumor cells
The number of circulating tumor cells will be measured by collecting 5ml of venous blood sample.
Time frame: immediately after the surgery
the number of circulating tumor cells
The number of circulating tumor cells will be measured by collecting 5ml of venous blood sample.
Time frame: on the 30 day after surgery
Visual Analogue Scale
Pain intensity will be assessed using the Visual Analogue Scale, which ranges from 0 to 10, with a higher score indicating greater pain intensity at 24 hours after surgery.
Time frame: at 24 hours after surgery
Visual Analogue Scale
Pain intensity will be assessed using the Visual Analogue Scale, which ranges from 0 to 10, with a higher score indicating greater pain intensity at 48 hours after surgery.
Time frame: at 48 hours after surgery
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.