Different PEEP Settings of COVID-19 Induced ARDS

Southeast University, China20 enrolled

Overview

This was a multi-center prospective study. All consecutive severe cases of COVID-19 whose PO2/FiO2\<300mmHg with invasive ventilation admitted to 5 fixed-point receive COVID-19 patients hospitals in Wuhan from 5 March to 15 March 2020 were included. Epidemiological, clinical data, lung mechanics, artery blood gas test and hemodynamics at three methods to titrate PEEP, optimizing oxygenation, optimizing compliance, ARDSnet. The study was approved by the Ethics Committee of Zhongda Hsopital, Southeast University.

After PEEP titration, PEEP settings could be set by optimizing oxygenation, optimizing compliance, ARDSnet.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

COVID-19 Mechanical Ventilation Pressure High Acute Respiratory Distress Syndrome

Interventions

Gas exchanges at different PEEPOTHER

Gas exchanges measurement at different PEEP

lung mechanics at different PEEPOTHER

lung mechanics measurement at different PEEP

Hemodynamics changes at different PEEPOTHER

Hemodynamics changes measurement at different PEEP

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * COVID-19 patients with mechanical ventilation * PO2/FIO2\<300mmHg * ages\>18 years Exclusion Criteria: * pneumothorax * pregnant * hemodynamics is unstable

Locations (1)

Zhongda Hospital, Southeast University

Nanjing, Jiangsu, China

Outcomes

Primary Outcomes

Respiratory system compliance improvement

the respiratory system compliance was compared among three groups

Time frame: 20 minutes

Secondary Outcomes

Gas echanges improvement

P/Fwere compared among three groups

Time frame: 20 minutes

Data from ClinicalTrials.gov

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