Study of the Association Between Presbycusis With the Incidence of Frailty

Universidad Europea de Madrid300 enrolled

Overview

The objective of the project is to establish the association between presbycusis and the incidence of frailty in humans in order to establish hearing loss with age as another index for the diagnosis of frailty; As well as studying the effect of exposure to polyphenols in the diet on presbycusis and frailty. Human study: volunteers between 60 and 99 years old, men and women during a period of 6 months, questions and answers, audiometries, study of fragility, analysis of antioxidants in blood, and samples of urine will be measured Total polyphenols and oxidant capacity.

Study Type

OBSERVATIONAL

Enrollment

300

Conditions

Presbycusis Frailty Syndrome Oxidative Stress

Eligibility

Sex: ALLMin age: 60 YearsMax age: 99 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age Exclusion Criteria: * Disease of the hearing system * Serious illness (e.g. tumor) * Dementia * Total dependence

Locations (1)

Outcomes

Primary Outcomes

Auditory function

study by pure tone audiometry, calculating an average of the thresholds of hearing at 0.5, 1, 2 and 4 kilohertz classifying according to their hearing thresholds to the participants in: normal hearing ≤ 25decibel, slight hearing loss = 26-40 decibel; Y moderate-greater hearing loss\> 40 decibel (according to the World Health Organization).

Time frame: 6 months

Frailty

Fragility will be determined at the beginning and at the end of the study period using the 5 Fried indexes: weakness, low speed, low physical activity, exhaustion and weight loss. Participants with 3 or more criteria are classified as fragile, with 1-2 criteria as pre-fragile, and those without any criteria are not considered fragile. Thus, individuals will be classified in the analyzes as non-fragile, pre-fragile and fragile.

Time frame: 6 months

Secondary Outcomes

Determination of total polyphenols in urine

24-hour urine samples using the method Folin -Ciocalteu.

Time frame: measured twice in each volunteer, at the beginning and end of the study period (6 months)

Blood analysis,

routine biochemistry and determination of: carotenoids, vitamins E and D

Time frame: It will be performed at the beginning and at end of the study period (6 months)

Microbiota

Stool microbiota analysis