A randomized, prospective study of the efficacy and safety of the first-line treatment in advanced central non-small cell lung cancer patients by anti-PD-1 / PD-L1 monoclonal antibody and chemotherapy versus anti-PD-1 / PD-L1 monoclonal antibody and chemotherapy combined with bronchoscopic microwave intervention
This study is a randomized, prospective study, which will analyze the efficacy and safety of the first-line treatment in advanced central non-small cell lung cancer patients by anti-PD-1 / PD-L1 monoclonal antibody and chemotherapy versus anti-PD-1 / PD-L1 monoclonal antibody and chemotherapy combined with bronchoscopic microwave intervention. The efficacy will include objective response rate, disease control rate, progression-free survival, and overall survival. The safety will include adverse events and quality of life.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
50
bronchoscopic microwave intervention
anti-PD-1 / PD-L1 monoclonal antibody and chemotherapy
objective response rate
objective response rate
Time frame: 6 weeks
progression-free survival
progression-free survival
Time frame: 1 years
disease control rate
disease control rate
Time frame: 6 weeks
overall survival
overall survival
Time frame: 2 years
adverse events
adverse events
Time frame: 3 weeks
quality of life score
quality of life score
Time frame: World Health Organization Quality of Life Scale-Brief (WHOQOL-BREF)score 0-100,higher scores mean a better outcome.
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