Based on data regarding the effect of colchicine on the modulation of immune system and decreasing cytokine release and inflammation the question arises whether colchicine, administered in a relatively low dose, could potentially have an effect on COVID-19 Polymerase chain reaction(PCR) positive patients .
80 Patients with positive nasopharyngeal swab PCR for COVID-19 which were not hypoxic but showed computed tomography involvement compatible with COVID-19 admitted in ward (not in Intensive care unit) included and randomized in to two groups. All patients received standard treatment protocol including essential minerals, vitamins as antioxidants, antibiotics and Kaletra while in one randomly assigned group colchicine would be added.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
80
1.5 mg loading then 0.5 mg BID P.O
SBMU
Tehran, Iran
Nooshin Dalili
Tehran, Iran
CRPxN/R ratio change
increasing inflammatory status
Time frame: 2 weeks
Clinical deterioration by the WHO definition
including change in fever or O2 Saturation
Time frame: 2 weeks
PCR Viral Load
change in RT-PCR
Time frame: 2 weeks
CT severity involvement index
change in CT involvement
Time frame: 2weeks
LDH change
change in LDH
Time frame: 2 weeks
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