Role of PET/MRI in Head and Neck Cancer

University of Pecs110 enrolled

Overview

Study aim was to investigate the diagnostic role of Positron Emission Tomography / Magnetic Resonance Imaging (PET/MRI) in head and neck cancer.

This study was assessed the role of Diffusion weighted imaging (DWI) in discriminating between benign and malignant lesions in Head and neck cancer as well as studying the relationship between glucose metabolism (18F-FDG) and Apparent diffusion coefficient (ADC) for better tumor assessment.

Study Type

OBSERVATIONAL

Enrollment

110

Conditions

Head and Neck Cancer Benign Neoplasm Malignant Neoplasm

Interventions

RadiotherapyRADIATION

Patients have received radiotherapy as a treatment modality for Head and neck cancer

Eligibility

Sex: ALLMin age: 41 YearsMax age: 88 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Proved Head and neck cancer * Underwent PET/CT and PET/MRI * Lymph nodes due to primary Head and neck cancer. For healthy subject: * No previous history of malignancy. * no inflammation or infection in the neck region. * lymph node size \<10mm. Exclusion Criteria: * patients treated before by radiotherapy / chemoradiotherapy * patients underwent surgery * artifacts

Outcomes

Primary Outcomes

Difference in Apparent diffusion coefficient value between benign and malignant lesions

Apparent diffusion coefficient (ADC) was measured from benign and malignant lymph nodes by drawing region of interest (ROI) on the most homogeneous and most solid part in the target lymph node. Higher ADC value in Benign lymph node means that there are more water molecules movement inside the lymph node, more water molecules movement resulting in higher Apparent diffusion coefficient value. in malignant nodes and due to more tumor tissue, the result is to have lower water molecules motion so, lower ADC value.

Time frame: Baseline

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.