Chronic Fatigue Etiology and Recovery in Covid-19 Patients: the Role of Fatigability

Centre Hospitalier Universitaire de Saint Etienne69 enrolled

Overview

Chronic fatigue is the most common and debilitating symptom in intensive care unit (ICU) survivors. Indeed, it has been widely reported that patients who stayed in ICU for prolonged periods report a feeling of tiredness for months to years after ICU discharge. This symptom seems particularly pronounced in Covid-19 patients and may affect their quality of life by decreasing their capacity to perform simple tasks of daily life. The aim of the present project is to determine whether deteriorated neuromuscular function (i.e. increased fatigability) is involved in the feeling of fatigue of Covid-19 patients. Because the causes of this feeling are multi-dimensional, a large battery of tests will allow us to better understand the origin of chronic fatigue. A better knowledge of chronic fatigue etiology and its recovery will allow to optimize rehabilitation treatments to shorten the persistence of chronic fatigue and in fine improve life quality.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Chronic Fatigue Syndrome Intensive Care Unit Muscle

Interventions

QuestionnairesOTHER

Quality of life Depression Physical pain Social provisions Quality of sleep

blood testBIOLOGICAL

complete blood count and cytokine concentration, TNF-alpha, LDL oxidized, AOPP, SOD, GPX, catalase, albumin, transthyretin, RBP, transferin, α-1 glycoprotein acide, ferritine, selenium, zinc, magnesium

Maximal effort testOTHER

The maximal effort test with VO2max recordings will be assessed during the first visit to the laboratory.

actigraphyDEVICE

assessment of sleep quality

Neuromuscular evaluationDEVICE

* The maximum isometric force produced by the knee extensors will be measured on the ergometer * the intensity of muscular electrical activity recorded by surface electromyography * Peripheral nerve stimulation * Transcranial magnetic stimulation * Magnetic resonance imaging

stool analysisOTHER

analyze the composition of the intestinal microbiote. concerns only the patients of Saint Etienne

food diaryOTHER

3 days of information to determine nutrient intakes. concerns only the patients of Saint Etienne

Eligibility

Sex: ALLMin age: 35 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria for patients who have been in intensive care : * Diagnosed with Covid-19 * Ventilated in ICU for at least 3 consecutive days * ICU discharge between 4 and 8 weeks * Approval received from a physician * Command of the French language Inclusion Criteria for patients who have NOT been in intensive care : * Diagnosed with Covid-19 : positive serological test or positive PCR test following nasopharyngeal swabbing * Approval received from a physician * Command of the French language Exclusion Criteria: * Taking neuroactive substances that can alter corticospinal excitability * Patients with co-morbidities leading to significant fatigue: e.g. cancerous pathologies, sleep apnea * Patients with neurodegenerative or neuromuscular disease * Contraindication to the application of a magnetic field * Contraindication to the practice of Magnetic Resonance Imaging * Participant is pregnant * Patients with psychiatric disorders * Paraplegic and hemiplegic patients * Addictive disorders

Locations (8)

CHU de Grenoble

Grenoble, France

Clinique de la Sauvegarde - Lyon

Lyon, France

Hôpital Croix Rousse - HCL

Lyon, France

Centre Hospitalier de Lyon Sud

Pierre-Bénite, France

Hôpital privé de la Loire

Saint-Etienne, France

Chu Saint-Etienne

Saint-Etienne, France

Clinique Mutualiste Saint Etienne

Saint-Etienne, France

Hôpital Henry Gabrielle

Saint-Genis-Laval, France