The Influence of an Acute Exacerbation During Pulmonary Rehabilitation in COPD Patients Awaiting Lung Transplantation

Klaus Kenn559 enrolled

Overview

Data from chronic obstructive pulmonary disease patients awaiting lung transplantation which performed a pulmonary rehabilitation program will be analyzed retrospectively. Acute exacerbations occur frequently in these patients and have a major impact on the course of the disease. This study investigates the prevalence and the impact of acute exacerbations during pulmonary Rehabilitation in patients with severe chronic obstructive pulmonary disease patients awaiting lung Transplantation that continued the Rehabilitation program despite an acute exacerbation. Data will be taken from the internal database of the reference center (Schoen Klinik Berchtesgadener Land, Schoenau, Germany) where these data were collected during clinical routine.

Study Type

OBSERVATIONAL

Enrollment

559

Conditions

Chronic Obstructive Pulmonary Disease

Interventions

Pulmonary RehabilitationOTHER

Patients performed a comprehensive pre-lung transplant inpatient pulmonary rehabilitation program for 4 to 5 weeks duration.

Medical Language ↔ Plain English

Inclusion Criteria: * confirmed diagnosis of chronic obstructive pulmonary disease including patients with alpha-1 antitrypsin deficiency * listed for lung Transplantation or in the Evaluation process for lung transplantation * performed a pulmonary rehabilitation program at the reference center Exclusion Criteria: * patients that discontinued the pulmonary Rehabilitation program due to any reason and could therefore not perform assessement tests at the end of regular Rehabilitation program

Outcomes

Primary Outcomes

Change in 6-minute walk distance

The 6-minute walk test will be performed in accordance to the Guidelines of the European Respiratory Society and the American Thoracic Society

Time frame: day 1 and last day of pulmonary rehabilitation

Change in Quality of life

health-related Quality of life will be assessed by the physical and mental health component score of the short form 36 health survey (score from 0 to 100 with higher scores indicating better quality of life)