Minor traumatic brain injury (mTBI) (Glasgow Coma Scale 13 to 15) represent 70 to 90% of traumatic brain injury. Different disorders may occur after a traumatic minor brain injury (somatic, cognitive or affective) within 2 weeks. For 10 to 20% these symptoms are persistent and are part of post-concussion syndrome. Today a small amount of tools to predict this syndrome are available. Cerebral CT scan, a routine test for mTBI, isn't relevant to predict the post concussion syndrome. In order to improve understanding of the evolution toward this complication, it seems relevant to run a multimodal study. Multiparameter MRI combined to psychological and sociological evaluations cold provide a better global perception.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Enrollment
11
IRM Sequences T1, T2, FLAIR, T2\*, Cerebral Blood Flow (CBF) et mean diffusivity (MD)
Chu Grenoble Alpes
Grenoble, France
Compare the mean lesion volume fraction found in multiparametric magnetic resonance imaging between patients with and without post-concussions syndrome, three months after a mild Traumatic Brain Injury.
Mean of cerebral volume fraction corresponding to lesions areas, found in multiparametrical magnetic resonance imaging (expressed as a percentage), 3 months after mild traumatic brain injury.
Time frame: 3 months
Describe correlation between anamnestic risk factors, demographic data and post-concussion syndrome occurence
Describe correlation between risk factor and the development of post-concussion syndrome. Describe risk factors as demographic factors and medical history correlated with the development of post-concussion syndrome. The risk factors studies will be: * Age (median in years) * Sex * Cohabitation status * Education * Daily consumption of alcohol * Smoking * Glasgow score * Loss of consciousness after the trauma * Associated injuries This information will be obtained using the medical record and by interviewing the patient. The presence of post-concussion syndrome will be defined using the Rivermead Post-concussion Symptoms Questionnaire. The presence of post-concussion syndrome will correspond to a score higher than 12.
Time frame: 3 months
Level of asymmetry of the signal between each hemisphere, for each magnetic resonance imagings equence, and with the techniques of ROI (Regions of Interests): asymmetry threshold corresponding to a lesion.
Measuring the level of asymmetry of the signal between each hemisphere, for each magnetic resonance imaging sequence, and with the techniques of ROI (Regions of Interests) ;to determine the asymmetry threshold corresponding to a lesion.
Time frame: 3 months
Graph metrics in resting-state functional magnetic resonance imaging in both groups
Describe the graph metrics in resting-state functional MRI in both groups
Time frame: 3 months
Clinical correlation of magnetic resonance imaging with symptoms.
Look for a clinical correlation between psychological evaluation tests and magnetic resonance imaging observations such as damages zones.
Time frame: 3 months
Describe in both groups, the evolution of symptomatology at one year
Describe in both groups, the evolution of symptomatology at one year with the Rivermead Post-Concussion Syndrome Questionnaire (RPCSQ). The Rivermead questionnaire ranges from 0 to 64. The presence of post-concussion syndrome will correspond to a score higher than 12.
Time frame: 12 months
Evaluate the impact of mTBI on patients' lifestyles
Sociologic interview to understand the impact of mTBI on patients' lifestyles and social insertion.
Time frame: 6 months
Evaluate the impact of mTBI on patients' lifestyles
Sociologic interview to understand the impact of mTBI on patients' lifestyles and social insertion.
Time frame: 12 months
Evaluate the impact of social characteristics at stake and the resources mobilized
Understand the impact of social characteristics at stake and the resources mobilized in the social life's re-establishment post TBI through a sociologic interview
Time frame: 6 months
Evaluate the impact of social characteristics and the resources mobilized
Understand the impact of social characteristics at stake and the resources mobilized in the social life's re-establishment post TBI through a sociologic interview
Time frame: 12 months
Evaluate the experience of mTBI and post-concussion syndrome through the patient's personal appreciation, the judgement of family and friends and the medical follow-up of the general practitioner.
Sociologic questionnaires to different actors of the patient recovery to understand the experience of mTBI and post-concussion syndrome : * the patient's personal appreciation, * the judgement of family and friends * the medical follow-up of the general practitioner.
Time frame: 6 months
Evaluate the experience of mTBI and post-concussion syndrome through the patient's personal appreciation, the judgement of family and friends and the medical follow-up of the general practitioner.
Sociologic questionnaires to different actors of the patient recovery to understand the experience of mTBI and post-concussion syndrome : * the patient's personal appreciation, * the judgement of family and friends * the medical follow-up of the general practitioner.
Time frame: 12 months
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