The University of the Philippines Hydroxychloroquine PEP Against COVID-19 Trial

Inclusion Criteria: * any medical or non-medical personnel of the Philippine General Hospital and the UP Manila National Institutes of Health to include physicians (consultants, fellows-in-training, residents-in-training); nurses and other nursing staff (nursing aide, institutional or utility worker); janitors and cleaning staff, medical technologists and personnel of the laboratory where the COVID PCR testing is done; technicians of the radiology department, electrocardiography (ECG) station, arterial blood gas (ABG) stations and other personnel employed by the hospital on a tenured, part-time or full-time,and temporary. Because of the sample size, there is also a plan to include also health care workers in the community quarantine centers in the Manila area such as the Rizal Coliseum or the Ninoy Aquino Stadium, or at the World Trade Center * aged 18-59 years * exposure to a probable or confirmed COVID19 case within 4 days prior to study enrollment that is considered to be medium or high risk as defined by the HICU * asymptomatic (no acute respiratory, flu-like, gastrointestinal signs and symptoms at the time of enrollment * negative baseline COVID19 RT-PCR test result\* * for female participants of child bearing potential they must agree to effective birth control methods during the clinical trial or abstinence from any sexual activity during the duration of the study. * Since RT-PCR result may not be released right away, volunteers who test positive after preliminary enrollment will be screen-failed and will not be included in the analysis. Exclusion Criteria: * active COVID19 disease: positive RT-PCR COVID19 test * prior COVID19 disease * weight less than 40kg or a BMI less than 18kg/m2 * current or recent hospitalization within the past year * known allergy to or intolerance of hydroxychloroquine (HCQ) or chloroquine (CQ) * current use of HCQ or CQ for whatever indications (malaria, lupus) * current use of other medication with known antiviral effects * current or known use in the last two weeks of known arrhythmogenic drugs or drugs that prolong the QT interval in the ECG, including but not limited to quinolones, macrolides, amiodarone, digoxin, flecainide, propafenone * any previous known or suspected retinopathy; in case of doubt, an ophthalmology clearance be secured prior to enrollment * known G6PD deficiency discovered through the newborn screening program or known intolerance or allergies to beans and any food that contains beans * women who are pregnant or breastfeeding, or a positive pregnancy test at baseline for women of child bearing age * history of known seizures or treatment with anti-epileptic medications * history of known existing arrhythmia * intake or use of anti diabetic agents especially sulfonylureas or any type of insulin * presence of abnormalities in baseline tests: 1. ECG abnormalities that are exclusionary: Baseline QTc \> 500 msec or QTc \> 550 msec in patients with wide QRS; any form of tachy- or bradyarrythmias NB: sinus arrhythmia is not exclusionary 2. CBC abnormalities showing anemia with hemoglobin value less than 12.5 g/dL or low platelet count or thrombocytopenia with platelet count less than 150,000 platelets per microliter 3. Creatinine levels above normal values: 60 to 110 micromoles per liter (0.7 to 1.2 mg/dL for men and 45 to 90 micromoles per liter (0.5 to 1.0 mg/dL) for women 4. ALT test that is elevated above 2x the upper limit of the normal: NV is 7 to 56 units per liter