It is supposed to monitor hypertensive patients who are infected or have clinical manifestations of COVID-19 for 1 month after the onset of the disease. Three groups will be considered: 1. receiving ACE inhibitors 2. receiving ARBs 3. receiving DIR.
POEM (Patient-Oriented Evidence that Matters) intervention is performed as an open prospective randomized two medical centres trial in subjects suffering from COVID-19 who have been receiving iRAS, either ACEi, ARB or DRi as basic antihypertensive therapy. COVID-19 is confirmed by a PCR test, the disease follow-up is divided into 2 periods: up to 12 weeks and up to 24 weeks. Primary Outcome Measure: BP was known one week before COVID-19 and is tested during the disease onset on weeks 2, 4, 12, 24. Secondary Outcome Measures are clinical features. Subanalysis in patients with CKD is additionally performed for those who have CKD.
Study Type
OBSERVATIONAL
Enrollment
112
routine drug intake
routine drug intake
routine drug intake
Medical Practice Prof D.Ivanov
Kiev, Please Select, Ukraine
Level of BP in mm Hg
BP in patients one week before COVID-19 infection and 2, 4, 12, 24 weeks follow-up after COVID-19 onset
Time frame: estimated at 2, 4, 12, 24 weeks after the start of COVID-19; data for 24 weeks are reported
Number of Patients With Fever Above 37.2 on COVID-19 Course
the number of patients with hypertension who received RASi and has a fever (above 37.2C) separately on 2, 4 and 12 weeks follow-up
Time frame: estimated at 2, 4, 12 weeks after the COVID-19 onset
Number of Patients With Cough in COVID-19 Course
the absolute number of patients with hypertension on RASi who have had a cough at 2, 4 and 12 weeks from COVID-19 onset
Time frame: on 2,4 and 12 week from COVID-19 onset
Number of Patients With Throat Pain in COVID-19 Course
the number of patients with hypertension on RASi with throat pain at 2, 4 and 12 weeks follow-up
Time frame: estimated at 2, 4, 12 weeks after the COVID-19 onset
Number of Patients With Diarrhea Inf COVID-19 Course
the number of patients with hypertension on RASi with diarrhoea at 2, 4 and 12 weeks of follow-up
Time frame: estimated at 2, 4, 12 weeks after the COVID-19 onset
Number of Patients Who Need to Apply to Hospital in COVID-19 Course
the number of patients with hypertension on RASi who need hospital and intensive care unit at 2, 4 and 12 weeks of follow-up
Time frame: estimated at 2, 4, 12 weeks after the COVID-19 onset
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