Intra-operative Variation in Size of Brain Tumors After Craniotomy

Sheri Kashmir Institute of Medical Sciences51 enrolled

Overview

We planned to evaluate the change in tumor dimensions of intraaxial parenchymal tumors after craniotomy by comparing the tumor size on intraoperative ultrasonography (IOUSG) with pre-operative CECT and CEMRI brain.

Background: No previous study to determine the intraoperative changes in the tumor dimensions had been undertaken previously. Objectives: We planned to evaluate the change in tumor dimensions of intraaxial parenchymal tumors after craniotomy by comparing the tumor size on intraoperative ultrasonography (IOUSG) with pre-operative CECT and CEMRI brain. Study Design: This was a prospective observational study. Participants: Patients aged 15-65 years undergoing surgery at SKIMS for intraaxial parenchymal intracranial tumors were included. Methods: Standard pre-operative CECT and CEMRI brain were done to measure tumor dimensions and compared with IOUSG.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Brain Tumor, Primary

Eligibility

Sex: ALLMin age: 15 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All patients above the age of 15 years conferring to Grade I and II of American Society of Anesthesiologist (ASA) physical status classification system, undergoing elective craniotomy with intracranial tumor excision were included in this study. Patients with or without any neuro-deficit were also included. Only those patients in whom all the tumor dimensions could be defined with precision on pre-operative CECT, CEMRI and IOUSG were included in the final analysis. Exclusion Criteria: * Patients' in whom there are multiple intracranial tumors (e.g. metastasis), deep seated tumors, inability to use IOUSG and in whom exact tumor dimensions cannot be defined either on pre-operative CECT/CEMRI or on IOUSG were excluded.

Locations (1)

Sher-i-Kashmir Institute of Medical Sciences, Soura

Srinagar, Jammu and Kashmir, India

Outcomes

Primary Outcomes

Tumor dimension change

Change in tumor dimension, surface area and volume when comparing intraoperative ultrasound with pre-operative CEMRI and CECT brain

Time frame: March 2018 to November 2019

Secondary Outcomes

Tumor distance from dural surface

Change in the distance of tumor from dural surface as measured on intraoperative ultrasound when comparing it with pre-operative CEMRI and CECT brain

Time frame: March 2018 to November 2019

Relationship of tumor size change with other characteristics

Relationship of tumor size change with tumor consistency, tumor characteristics, histopathology, tumor location

Time frame: March 2018 to November 2019

Data from ClinicalTrials.gov

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